Dibasic Benzo[<i>b</i>]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation

Abstract

ADVERTISEMENT RETURN TO ISSUELetterNEXTDibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding OrientationDaniel J. Sall, Jolie A. Bastian, Stephen L. Briggs, John A. Buben, Nickolay Y. Chirgadze, David K. Clawson, Michael L. Denney, Deborah D. Giera, Donetta S. Gifford-Moore, Richard W. Harper, Kenneth L. Hauser, Valentine J. Klimkowski, Todd J. Kohn, Ho-Shen Lin, Jefferson R. McCowan, Alan D. Palkowitz, Gerald F. Smith, Kumiko Takeuchi, Kenneth J. Thrasher, Jennifer M. Tinsley, Barbara G. Utterback, Sau-Chi B. Yan, and Minsheng ZhangView Author Information Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285 Cite this: J. Med. Chem. 1997, 40, 22, 3489–3493Publication Date (Web):October 24, 1997Publication History Received9 July 1997Published online24 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jm9704107https://doi.org/10.1021/jm9704107rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views439Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Inhibition,Inhibitors,Peptides and proteins,Reaction products,Thiophenes Get e-Alerts