John A. Buben

Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: A dose-effect study

John A. Buben, Ellen J. O’Flaherty · Toxicology and Applied Pharmacology · 1985 · 126 citations

Pharmacy, Pharmacokinetics, Toxicology +12

Dibasic Benzo[<i>b</i>]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation

Daniel J. Sall, Jolie Bastian, John A. Buben et al. · Journal of Medicinal Chemistry · 1997 · 54 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa:  Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity

Michael R. Wiley, Leonard C. Weir, Steven L. Briggs et al. · Journal of Medicinal Chemistry · 2000 · 46 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Microsomal metabolism and covalent binding of [³H/¹⁴C]-bromobenzene. Evidence for quinones as reactive metabolites

Paul Weller, John A. Buben, Robert A. Wiley et al. · Xenobiotica · 1988 · 38 citations

Pharmacy, Biochemistry, Toxicology +16

Diamino Benzo[<i>b</i>]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives

Daniel J. Sall, Dianna L. Bailey, Jolie Bastian et al. · Journal of Medicinal Chemistry · 2000 · 31 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17