Leonard C. Weir

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

J. Scott Sawyer, Bryan D. Anderson, Douglas W. Beight et al. · Journal of Medicinal Chemistry · 2003 · 237 citations · Full text

Drug Target, Pyrazole-based Inhibitors, Pharmaceutical Chemistry +20

<i>N</i>²-Aroylanthranilamide Inhibitors of Human Factor Xa

Ying K. Yee, Anne Louise Tebbe, Jared H. Linebarger et al. · Journal of Medicinal Chemistry · 2000 · 48 citations

Molecular Pharmacology, Medicinal Chemistry, Drug Target +14

Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa:  Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity

Michael R. Wiley, Leonard C. Weir, Steven L. Briggs et al. · Journal of Medicinal Chemistry · 2000 · 46 citations

Drug Target, Pharmacotherapy, Amidine-derived Inhibitors +20

D-Phe-Pro-p-Amidinobenzylamine: A potent and highly selective thrombin inhibitor

Michael R. Wiley, Nickolay Y. Chirgadze, David K. Clawson et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 41 citations

Thrombosis, Medicinal Chemistry, Biochemistry +9

Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-Agmatine and its homologs

Michael R. Wiley, Nickolay Y. Chirgadze, David K. Clawson et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 36 citations

Protease Inhibitors, Protein Chemistry, Protein Function +9