Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Richard H. Porter, Georg Jaeschke, Will Spooren et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 314 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

Will Spooren, A. Vassout, H.C. Neijt et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 266 citations

Medicine, Neuroscience, Pharmacology +15

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

Julie A. O’Brien, Wei Lemaire, Marion Wittmann et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 172 citations

Medicine, Neuroscience, Pharmacology +17

Treatment of Anxiety Using Fenobam (a Nonbenzodiazepine) in a Double-Blind Standard (Diazepam) Placebo-Controlled Study

John C. Pecknold, David McClure, LUIS APPELTAUER et al. · Journal of Clinical Psychopharmacology · 1982 · 170 citations

Pharmacy, Pharmacology, Pharmacotherapy +11

mGluR5 antagonists: discovery, characterization and drug development.

F. Gasparini, Graeme Bilbe, Baltazar Gomez‐Mancilla et al. · PubMed · 2008 · 63 citations

Life Sciences, Neuroscience, Pharmacology +15