The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt et al. · Science · 2003 · 3.5K citations

Primary Immunodeficiency, Human Retrovirus, T-regulatory Cell +14

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Immunogenetics, Lymphocyte Development, Immune Cell Development +7

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B. John, Christel Devaud, Connie P.M. Duong et al. · Clinical Cancer Research · 2013 · 688 citations

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

John Scholler, Troy Brady, Gwendolyn Binder-Scholl et al. · Science Translational Medicine · 2012 · 640 citations · Full text

Functional Dissection of the <i>Tol2</i> Transposable Element Identified the Minimal <i>cis</i>-Sequence and a Highly Repetitive Sequence in the Subterminal Region Essential for Transposition

Akihiro Urasaki, Ghislaine Morvan-Dubois, Koichi Kawakami · Genetics · 2006 · 545 citations · Full text

Genetics, Subterminal Region Essential, Molecular Biology +18