Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

Yasuyoshi Kawato, Masashi Aonuma, Yasuhide Hirota et al. · PubMed · 1991 · 874 citations

Medicine, Oncology, Pharmacology +13

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

William D. Kingsbury, Jeffrey C. Boehm, Dalia R. Jakas et al. · Journal of Medicinal Chemistry · 1991 · 516 citations

Medicine, Medicinal Chemistry, Pharmacology +10

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Robert Hertzberg, Mary Jo Caranfa, Kenneth G. Holden et al. · Journal of Medicinal Chemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Phase I and pharmacokinetic trial of weekly CPT-11.

Mace L. Rothenberg, John G. Kuhn, Howard A. Burris et al. · Journal of Clinical Oncology · 1993 · 303 citations

Medicine, Oncology, Pharmacology +16

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

N Kaneda, Hiroko Nagata, T Furuta et al. · PubMed · 1990 · 293 citations

Pharmacy, Pharmacokinetics, Pharmacology +11