Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

N Kaneda, Hiroko Nagata, T Furuta, +1

PubMed

Antitumor ActivityChemoprevention StrategyCamptothecin Analogue Cpt-11Cellular PharmacologyPharmacotherapy +17

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: Carbamate-Linked, Water-Soluble Derivatives of 7-Ethyl-10-hydroxycamptothecin.

Seigo Sawada, Satoru Okajima, Ritsuo Aiyama, +6

Chemical and Pharmaceutical Bulletin

Antitumor ActivityNovel 36Organic ChemistryChemical DerivativePharmaceutical Chemistry +14

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

Yasuyoshi Kawato, T Furuta, Masashi Aonuma, +3

Cancer Chemotherapy and Pharmacology

Tumor BiologyAntitumor ActivityNude MiceHuman Tumor XenograftsMedicine +6

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives: A-Ring Modified and 7,10-Disubstituted Camptothecins.

K Nokata, Hiroshi Nagata, T Furuta, +2

Chemical and Pharmaceutical Bulletin

Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives. A-Ring-Substituted 7-Ethylcamptothecins and Their E-Rig-Modified Water-Soluble Derivatives.

Takashi Yaegashi, Hiroshi Nagata, T Furuta, +1

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryAntitumor ActivityOrganic ChemistryHeterocycle ChemistryPharmaceutical Chemistry +14

Novel Acrylonitrile Derivatives, YHO-13177 and YHO-13351, Reverse BCRP/ABCG2-Mediated Drug Resistance<i>In Vitro</i>and<i>In Vivo</i>

Ryuta Yamazaki, Yukiko Nishiyama, T Furuta, +8

Molecular Cancer Therapeutics

Pharmaceutical SciencePharmacotherapyPharmaceutical ChemistryTumor BiologyDrug Resistance +17

[Effect of administration schedules on the antitumor activity of CPT-11, a camptothecin derivative].

T Furuta, Teruo Yokokura

PubMed

Tumor BiologyOncologyAntitumor ActivityPharmacologyAdministration Schedules +8

Chemical Modification of an Antitumor Alkaloid, 20(S)-Camptothecin. E-Lactone Ring-Modified Water-Soluble Derivatives of 7-Ethylcamptothecin.

Takashi Yaegashi, T Furuta, T Yokokura

Chemical and Pharmaceutical Bulletin

Bioorganic ChemistryChemical ModificationOrganic ChemistryChemical BiologyPharmaceutical Chemistry +17

[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

T Furuta, Teruo Yokokura, Masahiko Mutai

PubMed

Tumor BiologyWalker 256MedicinePharmacologyWistar Rat +10

Chemical Modification of Antitumor Alkaloids, 20(S)-Camptothecin and 7-Ethylcamptothecin: Reaction of the E-Lactone Ring Portion with Hydrazine Hydrate.

Takashi Yaegashi, T Furuta, T Yokokura, +1

Chemical and Pharmaceutical Bulletin

Hydrazine HydrateN-amino Lactam 6Medicinal ChemistryNatural Product SynthesisBiochemistry +13