HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

Paul Talalay, Mary Jane Long, Hans J. Prochaska · Proceedings of the National Academy of Sciences · 1988 · 594 citations · Full text

Medicine, Biochemistry, Oncology +17

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

Albena T. Dinkova‐Kostova, Michael A. Massiah, Richard E. Bozak et al. · Proceedings of the National Academy of Sciences · 2001 · 588 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Albena T. Dinkova‐Kostova, Karen T. Liby, Katherine K. Stephenson et al. · Proceedings of the National Academy of Sciences · 2005 · 566 citations

Life Sciences, Immunology, Pharmacology +17

HSF1 is required for extra‐embryonic development, postnatal growth and protection during inflammatory responses in mice

Xianzhong Xiao · The EMBO Journal · 1999 · 553 citations · Full text

Life Sciences, Developmental Biology, Immunology +14