Why High-error-rate Random Mutagenesis Libraries are Enriched in Functional and Improved Proteins

Natural Selection and the Concept of a Protein Space

John Maynard Smith · Nature · 1970 · 971 citations

Life Sciences, Biology, Molecular Biology +14

DNA shuffling of a family of genes from diverse species accelerates directed evolution

Andreas Crameri, Sun-Ai Raillard, Ericka Bermudez et al. · Nature · 1998 · 828 citations

Life Sciences, Genetics, Molecular Biology +13

Birthday paradox, coupon collectors, caching algorithms and self-organizing search

Philippe Flajolet, Danièle Gardy, Loÿs Thimonier · Discrete Applied Mathematics · 1992 · 482 citations · Full text

Computing, Computer Science, Computer Systems +16

Thermodynamic prediction of protein neutrality

Jesse D. Bloom, Jonathan J. Silberg, Claus O. Wilke et al. · Proceedings of the National Academy of Sciences · 2005 · 375 citations · Full text

Life Sciences, Biochemistry, Biophysics +13

An Approach to Random Mutagenesis of DNA Using Mixtures of Triphosphate Derivatives of Nucleoside Analogues

Manuela Zaccolo, David M. Williams, D. M. Brown et al. · Journal of Molecular Biology · 1996 · 320 citations

Life Sciences, Genetics, Molecular Biology +15