Concepedia

Error-prone Mutagenesis

Error-Prone Mutagenesis is a laboratory technique in directed evolution that introduces random mutations into a gene through error-prone DNA replication, thereby generating genetic diversity for the selection of novel or improved protein functions.

1.2K

Publications

95.6K

Citations

4.2K

Authors

1.1K

Institutions

Publications per year

2017–2026

137

Parents

Children

Publications

1.2K

Rapid and efficient site-specific mutagenesis without phenotypic selection.

Thomas A. Kunkel · Proceedings of the National Academy of Sciences · 1985 · 7.3K citations · Full text

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

Yanfang Fu, Jennifer A Foden, Cyd Khayter et al. · Nature Biotechnology · 2013 · 3.3K citations · Full text

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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

Keith C. Cheng, D S Cahill, Hiroshi Kasai et al. · Journal of Biological Chemistry · 1992 · 1.8K citations · Full text

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Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

Micheline K. Strand, Tomas A. Prolla, R. Michael Liskay et al. · Nature · 1993 · 1.1K citations

, , +13

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

James A. Gagnon, Eivind Valen, Summer B. Thyme et al. · PLoS ONE · 2014 · 996 citations · Full text

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1–5 of 1.2K

Authors

4.2K

  1. TA
    Thomas A. Kunkel

    National Institute of Environmental Health Sciences, United States

    29 publications · 11.1K citations

    26

    h-index

  2. RM
    Roel M. Schaaper

    National Institute of Environmental Health Sciences, United States

    19 publications · 2K citations

    19

    h-index

  3. BW
    Barry W. Glickman

    University of Victoria, Canada

    20 publications · 1.3K citations

    17

    h-index

  4. LA
    Lawrence A. Loeb

    University of Washington, United States

    17 publications · 3.3K citations

    16

    h-index

  5. RP
    Robert P. Fuchs

    Centre National de la Recherche Scientifique, France

    17 publications · 1.2K citations

    14

    h-index

1–5 of 4.2K

Institutions

1.1K

  1. National Institute of Environmental Health Sciences

    Durham, United States

    36 h-index

    119 publications

    10.3K citations

  2. National Institutes of Health

    Bethesda, United States

    31 h-index

    147 publications

    15.6K citations

  3. Massachusetts Institute of Technology

    Cambridge, United States

    27 h-index

    118 publications

    12.6K citations

  4. Harvard University

    Cambridge, United States

    26 h-index

    110 publications

    33.9K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    26 h-index

    117 publications

    5.6K citations

  6. University of Washington

    Seattle, United States

    20 h-index

    67 publications

    7.8K citations

  7. University of Southern California

    Los Angeles, United States

    18 h-index

    63 publications

    7.7K citations

  8. Duke Medical Center

    Durham, United States

    18 h-index

    39 publications

    4.5K citations

1–8 of 1.1K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 106 publications · 21K citations

    65

    h-index

  2. Nucleic Acids Research

    90 publications · 5.6K citations

    44

    h-index

  3. Journal of Biological Chemistry

    JBC · 51 publications · 6.4K citations

    40

    h-index

  4. Journal of Bacteriology

    JB · 66 publications · 3.3K citations

    36

    h-index

  5. Genetics

    37 publications · 2.9K citations

    26

    h-index

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