Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

Bruce N. Ames, Joyce McCann, Edith F. Yamasaki · Mutation Research/Environmental Mutagenesis and Related Subjects · 1975 · 7.4K citations

Pharmacy, Toxicology, Carcinogenesis +7

Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process

Takashi Sügimura · Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis · 1985 · 372 citations

Pharmacy, Food Science, Toxicology +14

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

James S. Felton, Mark G. Knize, Nancy H. Shen et al. · Carcinogenesis · 1986 · 287 citations

Pharmacy, Toxicology, Food Microbiology +12

Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract

Hiroko Ohgaki, Kaoru Kusama, Norio Matsukura et al. · Carcinogenesis · 1984 · 182 citations

Pharmacy, Toxicology, Carcinogenesis +13

Isolation and characterization of new mutagens from fried ground beef

James S. Felton, M. G. Knize, Caitlin V. Wood et al. · Carcinogenesis · 1984 · 180 citations

Agriculture, Food Science, Toxicology +9