p38 Kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

Life Sciences, Immunology, Molecular Biology +14

A mild, general method for conversion of esters to amides

Anwer Basha, Michael F. Lipton, Steven M. Weinreb · Tetrahedron Letters · 1977 · 560 citations

Natural Sciences, Chemistry, Organic Chemistry +3

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

Keith P. Wilson, Patricia G. McCaffrey, Kathy Hsiao et al. · Chemistry & Biology · 1997 · 275 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Titanate-Mediated Transesterifications with Functionalized Substrates

Dieter Seebàch, Ernst Hungerbühler, Reto Naef et al. · Synthesis · 1982 · 271 citations

Natural Sciences, Chemistry, Materials Science +14

Discovery of a new class of p38 kinase inhibitors

Jacques Dumas, Robert Sibley, Bernd Riedl et al. · Bioorganic & Medicinal Chemistry Letters · 2000 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11