Concepedia

Genetic Interaction Between NRAS and BRAF Mutations and PTEN/MMAC1 Inactivation in Melanoma

Hensin Tsao, Guang Yang, Vikas Goel, Heng Wu, Frank G. Haluska

Journal of Investigative Dermatology · 2004 · 466 citations · 23 references

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23

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

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Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

Pablo Rodriguez‐Viciana, Patricia H. Warne, Asim Khwaja et al. · Cell · 1997 · 1.1K citations · Full text

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

Xinyi Wu, Kristen Senechal, Mehran S. Neshat et al. · Proceedings of the National Academy of Sciences · 1998 · 692 citations · Full text

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Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation.

Kapaettu Satyamoorthy, Gang Li, Michelle R. Gerrero et al. · PubMed · 2003 · 435 citations

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