Concepedia

Publication | Open Access

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

DOIFull Paper Access

80

Citations

28

References

2012

Year

Chander Peddaboina, Daniel C. Jupiter, Steven Fletcher, Jeremy L. Yap, Arun Rai, Richard P. Tobin, Weihua Jiang, Philip A. Rascoe, M Karen Newell Rogers, W. Roy Smythe,
BMC Cancer

Abstract

Mcl-1, Bcl-xL and USP9X overexpression are tumor survival mechanisms protective against chemotherapy. USP9X inhibition increases tumor cell sensitivity to various chemotherapeutic agents including Bcl-2/Bcl-xL inhibitors.

References

YearCitations

Page 1