Mark F. van Delft

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized

Mark F. van Delft, Andrew H. Wei, Kylie D. Mason et al. · Cancer Cell · 2006 · 1.2K citations · Full text

Apoptosis, Immunology, Cell Death +4

Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

Simon N. Willis, Jamie I. Fletcher, Thomas Kaufmann et al. · Science · 2007 · 1.1K citations

Pro-survival Bcl-2-like Relatives, Signal Transduction, Bh3-only Members +11

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

Kate McArthur, Lachlan Whitehead, John M. Heddleston et al. · Science · 2018 · 952 citations

Mitophagy, Apoptosis, Immunology +18

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

M. J. D. White, Kate McArthur, Donald Metcalf et al. · Cell · 2014 · 918 citations · Full text

Mitochondrial Function, Apoptosis, Immunology +4

Structural insights into the degradation of Mcl-1 induced by BH3 domains

Peter E. Czabotar, Erinna F. Lee, Mark F. van Delft et al. · Proceedings of the National Academy of Sciences · 2007 · 437 citations · Full text

Protein Assembly, Apoptosis, Molecular Biology +18