Jeremy L. Yap

BRD4 Structure–Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536

Lijia Chen, Jeremy L. Yap, Makoto Yoshioka et al. · ACS Medicinal Chemistry Letters · 2015 · 89 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Focused Library +15

Perturbation of the c-Myc–Max Protein–Protein Interaction via Synthetic α-Helix Mimetics

Kwan‐Young Jung, Huabo Wang, Peter Teriete et al. · Journal of Medicinal Chemistry · 2015 · 88 citations · Full text

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

Xiaobo Cao, Jeremy L. Yap, M. Karen Newell‐Rogers et al. · Molecular Cancer · 2013 · 86 citations · Full text

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

Chander Peddaboina, Daniel C. Jupiter, Steven Fletcher et al. · BMC Cancer · 2012 · 80 citations · Full text

Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors

Jeremy L. Yap, Xiaobo Cao, Kenno Vanommeslaeghe et al. · Organic & Biomolecular Chemistry · 2012 · 58 citations