SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, +17

Nature

Signaling PathwayCell RegulationApoptosisImmunologyCellular Apoptosis +4

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, +18

Nature Cell Biology

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

Daming Gao, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, +14

Molecular Cell

Own ActivationSignal TransductionSignaling PathwayMtor Inhibitor DeptorScfβtrcp-dependent Degradation +9

Acetylation-Dependent Regulation of Skp2 Function

Hiroyuki Inuzuka, Daming Gao, Lydia W.S. Finley, +15

Cell

Transcriptional RegulationSignal TransductionMolecular RegulationCellular Regulatory MechanismFunctional Regulation +5

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

Hiroyuki Inuzuka, Alan Tseng, Daming Gao, +15

Cancer Cell

Protein FunctionSignal TransductionCasein KinaseMdm2 OncoproteinCell Regulation +11

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

Shavali Shaik, Holly M. Brown‐Borg, Manuchair Ebadi, +1

Neuroscience Letters

Mitochondrial LocalizationMitochondrial DynamicNatural SciencesAutophagyMolecular Biology +3

Cyclin C is a haploinsufficient tumour suppressor

Na Li, Anne Fassl, Joel M. Chick, +35

Nature Cell Biology

OncologyMedicineCyclin CTumor SuppressorCancer Biology +3

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

Sang Hyun Min, Alan W. Lau, Tae Ho Lee, +14

Molecular Cell

Protein FunctionProtein ExpressionCell RegulationBiochemistryNatural Sciences +9

APCCdc20 Suppresses Apoptosis through Targeting Bim for Ubiquitination and Destruction

Lixin Wan, Mingjia Tan, Jie Yang, +12

Developmental Cell

Cell RegulationApoptosisImmunologyCell DeathApccdc20 Suppresses Apoptosis +3

TRPC1-mediated Inhibition of 1-Methyl-4-phenylpyridinium Ion Neurotoxicity in Human SH-SY5Y Neuroblastoma Cells

Sunitha Bollimuntha, Brij B. Singh, Shavali Shaik, +2

Journal of Biological Chemistry