Concepedia

Nonsteroidal anti-inflammatory drugs lower Aβ42 and change presenilin 1 conformation

Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J. Bacskai, Matthew P. Frosch, Michael C. Irizarry, Bradley T. Hyman

Nature Medicine · 2004 · 199 citations · 12 references

DOI

Concepts

References

12

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

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Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

Giselle P. Lim, Fu Yang, Tinyi Chu et al. · Journal of Neuroscience · 2000 · 880 citations · Full text

, , +17

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

Jason L. Eriksen, Sarah A. Sagi, Tawnya E. Smith et al. · Journal of Clinical Investigation · 2003 · 620 citations · Full text

, , +17

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski et al. · Nature Cell Biology · 2000 · 520 citations

, , +13

Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease

Yan Qiao, Jianhua Zhang, Hantao Liu et al. · Journal of Neuroscience · 2003 · 469 citations · Full text

, , +17