Concepedia

HIF activation by pH-dependent nucleolar sequestration of VHL

Karim Mekhail, Lakshman Gunaratnam, Marie-Eve Bonicalzi, Stephen Lee

Nature Cell Biology · 2004 · 257 citations · 28 references

DOI

Concepts

References

28

On the Origin of Cancer Cells

Otto Warbürg · Science · 1956 · 13.3K citations

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Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O <sub>2</sub> -Regulated Prolyl Hydroxylation

Panu Jaakkola, David R. Mole, Ya‐Min Tian et al. · Science · 2001 · 5.5K citations

, , +17

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell, Michael S. Wiesener, Gin-Wen Chang et al. · Nature · 1999 · 5.2K citations

, , +14

Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model

Robert M. Sutherland · Science · 1988 · 1.8K citations

, , +17

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Yunjuan Sun, Kunlin Jin, Lin Xie et al. · Journal of Clinical Investigation · 2003 · 1.1K citations · Full text

, , +17