Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

Gerald Batist, Anil Tulpule, Birandra K. Sinha et al. · Journal of Biological Chemistry · 1986 · 790 citations · Full text

Molecular Pharmacology, Breast Oncology, Chemoprevention Strategy +14

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

Kenneth H. Cowan, Gerald Batist, Anil Tulpule et al. · Proceedings of the National Academy of Sciences · 1986 · 297 citations · Full text

Tumor Biology, Doxr Mcf7 Cells, Breast Oncology +15

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

David J. Waxman · PubMed · 1990 · 259 citations

Modulation Chemotherapy, Pharmacotherapy, Metronomic Chemotherapy +19

Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects

Alex D. Lewis, John D. Hayes, C. Roland Wolf · Carcinogenesis · 1988 · 222 citations

Intrinsic Differences, Lipid Peroxidation, Gynecology +18

Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.

Kenneth D. Tew, A M Bomber, Sandra J. Hoffman · PubMed · 1988 · 212 citations

Ethacrynic Acid, Cellular Pharmacology, Pharmacotherapy +18