Concepedia

Conjugation Reactions

Conjugation Reactions is a class of phase II biotransformation reactions in drug metabolism in which a xenobiotic or its metabolite is covalently linked to an endogenous, usually activated, polar moiety (such as glucuronic acid, sulfate, acetate, amino acids, or glutathione), thereby forming more hydrophilic and typically less pharmacologically active products that are more readily eliminated.

6.6K

Publications

306.4K

Citations

21.8K

Authors

3.3K

Institutions

Publications per year

2017–2026

762

Variants

Phase Ii Biotransformation Reactions

Parents

Children

Publications

6.6K

Glutathione S-Transferases

William H. Habig, M. Pabst, William B. Jakoby · Journal of Biological Chemistry · 1974 · 18.1K citations · Full text

, , +15

Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism

Sally Pemble, Karsten Schroeder, S R Spencer et al. · Biochemical Journal · 1994 · 1.3K citations · Full text

, , +15

Selective Modification of Glutathione Metabolism

Alton Meister · Science · 1983 · 1.3K citations

, , +16

Chlorogenic acids and other cinnamates - nature, occurrence and dietary burden

Michael N. Clifford · Journal of the Science of Food and Agriculture · 1999 · 1.3K citations

, , +10

Chlorogenic acids and other cinnamates - nature, occurrence, dietary burden, absorption and metabolism

Michael N. Clifford · Journal of the Science of Food and Agriculture · 2000 · 902 citations

, , +8

1–5 of 6.6K

Authors

21.8K

  1. PJ
    Peter J. van Bladeren

    Wageningen University & Research, Netherlands

    24 publications · 1.9K citations

    22

    h-index

  2. BM
    Bengt Mannervik

    Uppsala University, Sweden

    20 publications · 2.5K citations

    19

    h-index

  3. KM
    Keiji Maruoka

    Kyoto University, Japan

    20 publications · 1.1K citations

    18

    h-index

  4. GJ
    Gerard J. Mulder

    Leiden University, Netherlands

    19 publications · 753 citations

    16

    h-index

  5. AA
    Alexandre Alexakis

    University of Geneva, Switzerland

    16 publications · 2.2K citations

    16

    h-index

1–5 of 21.8K

Institutions

3.3K

  1. Centre National de la Recherche Scientifique

    Paris, France

    42 h-index

    522 publications

    18.6K citations

  2. Kyoto University

    Kyoto, Japan

    38 h-index

    323 publications

    14K citations

  3. Chinese Academy of Sciences

    Beijing, China

    36 h-index

    292 publications

    15.1K citations

  4. University of Washington

    Seattle, United States

    27 h-index

    138 publications

    7.2K citations

  5. The University of Tokyo

    Tokyo, Japan

    26 h-index

    114 publications

    5.6K citations

  6. National Institutes of Health

    Bethesda, United States

    24 h-index

    90 publications

    61K citations

  7. University of Wisconsin–Madison

    Madison, United States

    23 h-index

    90 publications

    5.8K citations

  8. University of Oxford

    Oxford, United Kingdom

    23 h-index

    147 publications

    7.2K citations

1–8 of 3.3K

Venues

  1. Journal of the American Chemical Society

    JACS · 367 publications · 25.9K citations

    90

    h-index

  2. The Journal of Organic Chemistry

    JOC · 475 publications · 18.3K citations

    64

    h-index

  3. Bioconjugate Chemistry

    165 publications · 8.3K citations

    51

    h-index

  4. Tetrahedron Letters

    380 publications · 11.9K citations

    50

    h-index

  5. Journal of Biological Chemistry

    JBC · 107 publications · 25K citations

    49

    h-index

1–5