Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Elizabeth H. Corder, Ann M. Saunders, Warren J. Strittmatter et al. · Science · 1993 · 9.5K citations

Life Sciences, Genetics, Neurology +17

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Life Sciences, Genetics, Neurology +17

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Elizabeth H. Corder, Ann M. Saunders, Neil Risch et al. · Nature Genetics · 1994 · 1.9K citations

Medicine, Genetics, Neurology +16

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass, Michael G. Schlossmacher, Albert Y. Hung et al. · Nature · 1992 · 1.9K citations

Life Sciences, Biochemistry, Cell Biology +15

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Takeshi Iwatsubo, Asano Odaka, Nobuhiro Suzuki et al. · Neuron · 1994 · 1.8K citations

Life Sciences, Neuroscience, Pathology +16