HDAC6 as a target for antileukemic drugs in acute myeloid leukemia

HDAC6 is a microtubule-associated deacetylase

Charlotte Hubbert, Amaris R. Guardiola, Rong Shao et al. · Nature · 2002 · 2.4K citations

Life Sciences, Biochemistry, Molecular Biology +5

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Stephen J. Haggarty, Kathryn M. Koeller, Jason Chun Yu Wong et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Oncology +12

Azacitidine Prolongs Overall Survival Compared With Conventional Care Regimens in Elderly Patients With Low Bone Marrow Blast Count Acute Myeloid Leukemia

Pierre Fenaux, Ghulam J. Mufti, Eva Hellström‐Lindberg et al. · Journal of Clinical Oncology · 2009 · 958 citations · Full text

Medicine, Oncology, Pharmacology +13

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

Purva Bali, Michael Pranpat, James E. Bradner et al. · Journal of Biological Chemistry · 2005 · 749 citations · Full text

Life Sciences, Molecular Biology, Oncology +17