Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

Purva Bali, Michael Pranpat, James E. Bradner, +9

Journal of Biological Chemistry

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

Heh‐In Im, Jonathan A. Hollander, Purva Bali, +1

Nature Neuroscience

Molecular PharmacologyBdnf ExpressionMolecular PhysiologyMolecular NeuroscienceAddiction +7

Striatal microRNA controls cocaine intake through CREB signalling

Jonathan A. Hollander, Heh‐In Im, Antonio L. Amelio, +7

Nature

AddictionNeurotransmitterNeuropharmacologyNeuroscienceStriatal Microrna Controls +2

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3

Prince George, Purva Bali, Srinivas Annavarapu, +8

Blood

Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

Ramadevi Nimmanapalli, Lianne Fuino, Purva Bali, +9

PubMed

Histone ModificationsMixed-phenotype Acute LeukemiaCell DeathLowers ExpressionEpigenetics +16

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.

Lianne Fuino, Purva Bali, Sylvie Wittmann, +6

PubMed

Histone ModificationsBreast OncologyCancer BiologyEpigeneticsTumor Biology +15

Abrogation of Heat Shock Protein 70 Induction as a Strategy to Increase Antileukemia Activity of Heat Shock Protein 90 Inhibitor 17-Allylamino-Demethoxy Geldanamycin

Fei Guo, Kathy Rocha, Purva Bali, +9

Cancer Research

ApoptosisImmunologyCell DeathIncrease Antileukemia ActivityPharmaceutical Chemistry +16

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Fei Guo, Celia Sigua, Jianguo Tao, +7

Cancer Research

Cinnamic Acid HydroxamateHematological MalignancyCell SignalingMedicineApoptosis +10

Activity of Suberoylanilide Hydroxamic Acid Against Human Breast Cancer Cells with Amplification of Her-2

Purva Bali, Michael Pranpat, Ramona F. Swaby, +7

Clinical Cancer Research

Mechanistic role of heat shock protein 70 in Bcr-Abl–mediated resistance to apoptosis in human acute leukemia cells

Fei Guo, Celia Sigua, Purva Bali, +10

Blood