Lianne Fuino

Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.

Ramadevi Nimmanapalli, Lianne Fuino, Purva Bali et al. · PubMed · 2003 · 280 citations

Life Sciences, Oncology, Pharmacology +17

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.

Lianne Fuino, Purva Bali, Sylvie Wittmann et al. · PubMed · 2003 · 261 citations

Life Sciences, Molecular Biology, Oncology +17

Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl–positive human acute leukemia cells

Ramadevi Nimmanapalli, Lianne Fuino, Corinne Stobaugh et al. · Blood · 2003 · 221 citations · Full text

Life Sciences, Oncology, Pharmacology +12

Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells.

Ramadevi Nimmanapalli, Purva Bali, Erica O’Bryan et al. · PubMed · 2003 · 49 citations

Life Sciences, Oncology, Pharmacology +16