Design, synthesis, and anti-integrase activity of catechol–DKA hybrids

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

Daria J. Hazuda, Peter J. Felock, Marc Witmer et al. · Science · 2000 · 1.1K citations

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

Yehuda Goldgur, Robert Craigie, Gerson H. Cohen et al. · Proceedings of the National Academy of Sciences · 1999 · 494 citations

Life Sciences, Biochemistry, Molecular Biology +16

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 396 citations

Life Sciences, Biology, Molecular Biology +17

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

John Wai, Melissa S. Egbertson, Linda S. Payne et al. · Journal of Medicinal Chemistry · 2000 · 187 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +11

Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase:  Implication for Binding to Two Metal Ions on the Active Site of Integrase

Ya-Qiu Long, Xiao-Hua Jiang, Raveendra Dayam et al. · Journal of Medicinal Chemistry · 2004 · 183 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17