Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase:  Implication for Binding to Two Metal Ions on the Active Site of Integrase

Ya-Qiu Long, Xiao-Hua Jiang, Raveendra Dayam, +4

Journal of Medicinal Chemistry

Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors

Sijiu Liu, Li‐Fan Zeng, Wu Li, +5

Journal of the American Chemical Society

Drug TargetMolecular BiologyChemical BiologyReceptor Tyrosine KinaseBiochemistry +14

Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75

Bo-Wen Li, Feng-Hua Zhang, Erik Serrao, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesAntiviral Drug Development +8

Repositioning HIV-1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties

Li‐Fan Zeng, Yong Wang, Roza Kazemi, +11

Journal of Medicinal Chemistry

Combinatorial ChemistryHiv-1 IntegraseBioorganic ChemistryNovel AnaloguesPharmacotherapy +16

Discovery of a Novel Nonphosphorylated Pentapeptide Motif Displaying High Affinity for Grb2-SH2 Domain by the Utilization of 3‘-Substituted Tyrosine Derivatives

Yan-Li Song, Megan L. Peach, Peter P. Roller, +3

Journal of Medicinal Chemistry

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: A scaffold hopping approach using salicylate and catechol groups

Xing Fan, Feng-Hua Zhang, Rasha I. Al-Safi, +7

Bioorganic & Medicinal Chemistry

Catalytic DomainBiochemistryCatechol GroupsMedicineAntiviral Drug Development +8

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

Erik Serrao, Zhong-Liang Xu, Bikash Debnath, +4

Bioorganic & Medicinal Chemistry

Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors

Li‐Fan Zeng, Hu-Shan Zhang, Yun-Hua Wang, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryEngineeringMedicineDrug DiscoveryOrganic Chemistry +7

Design of Cell-Permeable Stapled Peptides as HIV-1 Integrase Inhibitors

Ya-Qiu Long, Shao-Xu Huang, Zahrah Zawahir, +8

Journal of Medicinal Chemistry

Hiv-1 IntegrasePeptide EngineeringMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +14

Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin

Krzysztof Krajewski, Christophe Marchand, Ya-Qiu Long, +2

Bioorganic & Medicinal Chemistry Letters

Tetrameric AnalogsBiochemistryMedicineAntiviral Drug DevelopmentAntiviral Therapy +5