Concepedia

Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence

Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Shin-ichi Iida, Hidetoshi Tahara, Keiko Nakayama, Keiichi I. Nakayama, Toshinori Ide, Hideyuki Saya, Eiji Hara

Nature Cell Biology · 2006 · 516 citations · 26 references

DOI

Concepts

References

26

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

, , +10

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Kaikobad Irani, Yong Xia, Jay L. Zweíer et al. · Science · 1997 · 1.6K citations

, , +17

Reversal of human cellular senescence: roles of the p53 and p16 pathways

Christian Beauséjour, Ana Krtolica, Francesco Galimi et al. · The EMBO Journal · 2003 · 1.4K citations · Full text

, , +14

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Andrew Lee, Brett E. Fenster, Hideki Ito et al. · Journal of Biological Chemistry · 1999 · 682 citations · Full text

, , +17

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Naoko Ohtani, Zoë Zebedee, Thomas J. G. Huot et al. · Nature · 2001 · 641 citations

, , +14