The "p16INK4a Pathway" is a molecular signaling cascade that belongs to the class of tumor suppressor pathways, specifically distinguished by its activation of the cyclin-dependent kinase inhibitor p16INK4a to induce cell cycle arrest in response to cellular stress and senescence stimuli.
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2017–2026
170
Variants
P16ink4a Signaling Pathway
Publications
1.1K
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.6K citations · Full text
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
Manuel Serrano, Han‐Woong Lee, Lynda Chin et al. · Cell · 1996 · 1.6K citations · Full text
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel et al. · Cell · 1997 · 1.6K citations · Full text
Ink4a/Arf expression is a biomarker of aging
Janakiraman Krishnamurthy, Chad Torrice, Matthew R. Ramsey et al. · Journal of Clinical Investigation · 2004 · 1.5K citations · Full text
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- NENorman E. Sharpless
University of North Carolina at Chapel Hill, United States
23 publications · 8K citations
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- GPGordon Peters
The Honourable Society of Lincoln's Inn, United Kingdom
16 publications · 1.8K citations
15
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- AAAbdelilah Aboussekhra
King Faisal Specialist Hospital & Research Centre, Saudi Arabia
13 publications · 560 citations
13
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- JKJanakiraman Krishnamurthy
University of North Carolina at Chapel Hill, United States
12 publications · 5K citations
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- EH
11
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University of North Carolina at Chapel Hill
Chapel Hill, United States
34 h-index
158 publications
28.7K citations
Harvard University
Cambridge, United States
21 h-index
98 publications
25.6K citations
Inserm
Paris, France
21 h-index
166 publications
8.6K citations
Johns Hopkins University
Baltimore, United States
20 h-index
97 publications
11K citations
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
19 h-index
80 publications
21.4K citations
The University of Texas MD Anderson Cancer Center
Houston, United States
18 h-index
109 publications
8K citations
Heidelberg University
Heidelberg, Germany
18 h-index
143 publications
51.2K citations
Howard Hughes Medical Institute
Chevy Chase, United States
16 h-index
50 publications
24.4K citations
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- Oncogene
68 publications · 6.3K citations
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- PubMed
Repository · 82 publications · 5.9K citations
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- Blood
25 publications · 2.2K citations
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- Cancer Research
24 publications · 3K citations
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- Journal of Biological Chemistry
JBC · 18 publications · 1.7K citations
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