Concepedia

Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitors

Rita Scarpelli, Julia K. Boueres, Mauro Cerretani, Federica Ferrigno, Jesus M. Ontoria, Michael Rowley, Carsten Schultz‐Fademrecht, Carlo Toniatti, Philip Jones

Bioorganic & Medicinal Chemistry Letters · 2009 · 22 citations · 12 references

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12

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers

Peter C.C. Fong, David S. Boss, Timothy A. Yap et al. · New England Journal of Medicine · 2009 · 3.6K citations · Full text

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(ADP-ribose)n participates in DNA excision repair

Barbara W. Durkacz, Olusesan Omidiji, Douglas A. Gray et al. · Nature · 1980 · 1.1K citations

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Josiane Ménissier de Murcia, C. Niedergang, Carlotta Trucco et al. · Proceedings of the National Academy of Sciences · 1997 · 1.1K citations · Full text

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