Federica Ferrigno

Discovery of 2-{4-[(3<i>S</i>)-Piperidin-3-yl]phenyl}-2<i>H</i>-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors

Philip Jones, Sergio Altamura, Julia K. Boueres et al. · Journal of Medicinal Chemistry · 2009 · 305 citations · Full text

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

Matthew J. Bottomley, Paola Lo Surdo, Paolo Di Giovine et al. · Journal of Biological Chemistry · 2008 · 302 citations · Full text

Histone Modifications, Histone Deacetylases, Class Iia +17

2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors

Philip Jones, Matthew J. Bottomley, Ottavia Cecchetti et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 64 citations · Full text

Medicinal Chemistry, Novel Series, Medicine +6

Identification of Novel, Selective, and Stable Inhibitors of Class II Histone Deacetylases. Validation Studies of the Inhibition of the Enzymatic Activity of HDAC4 by Small Molecules as a Novel Approach for Cancer Therapy

Jesus M. Ontoria, Sergio Altamura, Annalise Di Marco et al. · Journal of Medicinal Chemistry · 2009 · 61 citations · Full text

2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors

Ester Muraglia, Sergio Altamura, Danila Branca et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 53 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +10