Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.4K citations

Single Crispr Array, Engineering, Short Rnas +12

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

Minoru Takata, Masao S. Sasaki, Eiichiro Sonoda et al. · The EMBO Journal · 1998 · 1.2K citations · Full text

Chromatin, Genome Instability, Dna Damage +10

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Cristina Escribano‐Diaz, Alexandre Orthwein, Amélie Fradet‐Turcotte et al. · Molecular Cell · 2013 · 891 citations · Full text

Chromatin, Genome Instability, Cell Regulation +8

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Enriqueta Riballo, Martin Kühne, Nicole Rief et al. · Molecular Cell · 2004 · 826 citations · Full text

Genome Instability, Transcriptional Regulation, Protein Function +8

XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

Peter Ahnesorg, Philippa Smith, Stephen P. Jackson · Cell · 2006 · 758 citations · Full text

Chromatin, Genome Instability, Transcriptional Regulation +9