Alexandre Orthwein

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Cristina Escribano‐Diaz, Alexandre Orthwein, Amélie Fradet‐Turcotte et al. · Molecular Cell · 2013 · 891 citations · Full text

Chromatin, Genome Instability, Cell Regulation +8

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

Amélie Fradet‐Turcotte, Marella D. Canny, Cristina Escribano‐Diaz et al. · Nature · 2013 · 670 citations

Chromatin, Genome Instability, Chromatin Remodeling +8

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Paz Polak, Jaegil Kim, Lior Z. Braunstein et al. · Nature Genetics · 2017 · 515 citations · Full text

Genome Instability, Somatic Variant, Medicine +8

RETRACTED ARTICLE: A mechanism for the suppression of homologous recombination in G1 cells

Alexandre Orthwein, Sylvie M. Noordermeer, Marcus D. Wilson et al. · Nature · 2015 · 472 citations · Full text

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

Alexandre Orthwein, Amélie Fradet‐Turcotte, Sylvie M. Noordermeer et al. · Science · 2014 · 318 citations