Concepedia

Ku Protein Binding

Ku Protein Binding is a molecular recognition mechanism in which the Ku heterodimeric protein complex specifically binds to double-strand DNA breaks, serving as the initial step in the non-homologous end joining pathway of DNA repair.

427

Publications

35.2K

Citations

1.8K

Authors

529

Institutions

Publications per year

2017–2026

45

Parents

Publications

427

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Tanya Gottlieb, Stephen P. Jackson · Cell · 1993 · 1.2K citations

, , +14

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

John R. Walker, Richard A. Corpina, Jonathan M. Goldberg · Nature · 2001 · 1.2K citations

, , +14

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

Guillermo E. Taccioli, Tanya Gottlieb, T Blunt et al. · Science · 1994 · 636 citations

, , +16

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Michael J. Difilippantonio, Jie Zhu, Hua Tang Chen et al. · Nature · 2000 · 547 citations · Full text

, , +16

Mechanism of interaction between Ku protein and DNA.

Tsuneyo Mimori, John Hardin · Journal of Biological Chemistry · 1986 · 489 citations · Full text

, , +17

1–5 of 427

Authors

1.8K

  1. DJ
    David J. Chen

    The University of Texas Southwestern Medical Center, United States

    13 publications · 1.4K citations

    13

    h-index

  2. SP
    Stephen P. Jackson

    The Gurdon Institute, United Kingdom

    12 publications · 3.9K citations

    12

    h-index

  3. WH
    Westley H. Reeves

    University of Florida, United States

    12 publications · 621 citations

    12

    h-index

  4. TM
    Tsuneyo Mimori

    Kyoto University, Japan

    11 publications · 1.3K citations

    11

    h-index

  5. MK
    Manabu Koike

    National Institutes for Quantum Science and Technology, Japan

    10 publications · 272 citations

    10

    h-index

1–5 of 1.8K

Institutions

529

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    124 publications

    9.1K citations

  2. National Institutes of Health

    Bethesda, United States

    18 h-index

    50 publications

    9.1K citations

  3. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    17 h-index

    69 publications

    5.1K citations

  4. University of Cambridge

    Cambridge, United Kingdom

    14 h-index

    61 publications

    9.1K citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    13 h-index

    43 publications

    4.4K citations

  6. Augusta University

    Augusta, United States

    13 h-index

    34 publications

    3K citations

  7. Baylor College of Medicine

    Houston, United States

    13 h-index

    53 publications

    4.4K citations

  8. Institut de Pharmacologie et de Biologie Structurale

    Toulouse, France

    13 h-index

    46 publications

    3.2K citations

1–8 of 529

Venues

  1. Journal of Biological Chemistry

    JBC · 75 publications · 7.6K citations

    51

    h-index

  2. Nucleic Acids Research

    38 publications · 2.6K citations

    27

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.9K citations

    19

    h-index

  4. Molecular and Cellular Biology

    MCB · 18 publications · 2.1K citations

    18

    h-index

  5. DNA repair

    14 publications · 891 citations

    14

    h-index

1–5