Concepedia

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Jeffrey L. Cleland, Xanthe M. Lam, Brent S. Kendrick, Janet Z. Yang, Tzung‐Horng Yang, David E. Overcashier, Dennis E. Brooks, Chung Y. Hsu, John F. Carpenter

Journal of Pharmaceutical Sciences · 2001 · 288 citations · 31 references

DOI

Concepts

References

31

Humanization of an anti-p185HER2 antibody for human cancer therapy.

Paul Carter, Leonard G. Presta, C Gorman et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations

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Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers

Steven J. Prestrelski, Nicole I. Tedeschi, Tsutomu Arakawa et al. · Biophysical Journal · 1993 · 717 citations · Full text

, , +12

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

Jeffrey L. Cleland, Melissa Powell, S J Shire · PubMed · 1993 · 542 citations

, , +17

Hydrogen Bonding between Sugar and Protein Is Responsible for Inhibition of Dehydration-Induced Protein Unfolding

Steven Allison, Byeong S. Chang, Theodore W. Randolph et al. · Archives of Biochemistry and Biophysics · 1999 · 538 citations

, , +14

Identification of multiple sources of charge heterogeneity in a recombinant antibody

Reed J. Harris, Bruce Kabakoff, Frank Macchi et al. · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 503 citations

, , +16