Concepedia

Protein Stabilizers

"Protein Stabilizer" is a parenteral excipient belonging to the class of stabilization additives that specifically maintains the conformational integrity and functional activity of therapeutic proteins by inhibiting physical and chemical degradation pathways such as aggregation, adsorption, and denaturation.

165

Publications

9.3K

Citations

713

Authors

287

Institutions

Publications per year

2017–2026

38

Variants

Protein Stabilization Additives

Parents

Publications

165

Thermodynamic and kinetic examination of protein stabilization by glycerol

Kunihiko Gekko, Serge N. Timasheff · Biochemistry · 1981 · 480 citations

, , +11

The Peptide Backbone Plays a Dominant Role in Protein Stabilization by Naturally Occurring Osmolytes

Yufeng Liu, D. Wayne Bolen · Biochemistry · 1995 · 455 citations

, , +12

Outstanding Stability of Particle-Stabilized Bubbles

Zhiping Du, Maria P. Bilbao-Montoya, Bernard P. Binks et al. · Langmuir · 2003 · 325 citations

, , +16

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Jeffrey L. Cleland, Xanthe M. Lam, Brent S. Kendrick et al. · Journal of Pharmaceutical Sciences · 2001 · 288 citations

, , +14

Solvent denaturation and stabilization of globular proteins

Darwin O. V. Alonso, Ken A. Dill · Biochemistry · 1991 · 264 citations

, , +7

1–5 of 165

Authors

713

  1. CR
    C. Russell Middaugh

    University of Kansas, United States

    5 publications · 261 citations

    5

    h-index

  2. JF
    John F. Carpenter

    University of Colorado Boulder, United States

    5 publications · 581 citations

    5

    h-index

  3. SF
    Salvador F. Ausar

    Centro de Excelencia en Procesos y Productos de Córdoba, Argentina

    3 publications · 170 citations

    3

    h-index

  4. TI
    Taiji Imoto

    Kyushu University, Japan

    2 publications · 39 citations

    2

    h-index

  5. JL
    Jeffrey L. Cleland

    University of Colorado Health, United States

    2 publications · 303 citations

    2

    h-index

1–5 of 713

Institutions

287

  1. University of Kansas

    Lawrence, United States

    6 h-index

    22 publications

    1.2K citations

  2. Johns Hopkins University

    Baltimore, United States

    4 h-index

    5 publications

    186 citations

  3. University of Colorado Boulder

    Boulder, United States

    4 h-index

    8 publications

    675 citations

  4. Universidade Nova de Lisboa

    Lisbon, Portugal

    3 h-index

    14 publications

    584 citations

  5. NOF Corporation (Japan)

    Tokyo, Japan

    3 h-index

    3 publications

    94 citations

  6. National Cancer Institute

    Bethesda, United States

    3 h-index

    9 publications

    188 citations

  7. University of California, San Francisco

    San Francisco, United States

    3 h-index

    5 publications

    523 citations

  8. University of Colorado Health

    Aurora, United States

    3 h-index

    7 publications

    895 citations

1–8 of 287

Venues

  1. Biochemistry

    13 publications · 2K citations

    13

    h-index

  2. Journal of Pharmaceutical Sciences

    6 publications · 573 citations

    6

    h-index

  3. Journal of the American Chemical Society

    JACS · 4 publications · 199 citations

    4

    h-index

  4. Journal of Biological Chemistry

    JBC · 4 publications · 254 citations

    4

    h-index

  5. PLoS ONE

    4 publications · 207 citations

    4

    h-index

1–5