Mutational Patterns Associated with the 69 Insertion Complex in Multi-drug-resistant HIV-1 Reverse Transcriptase that Confer Increased Excision Activity and High-level Resistance to Zidovudine

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

Life Sciences, Infectious Diseases, Analytical Chemistry +12

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

Huifang Huang, Rajiv Chopra, Gregory L. Verdine et al. · Science · 1998 · 1.4K citations

Life Sciences, Biochemistry, Molecular Biology +17

A Novel Phenotypic Drug Susceptibility Assay for Human Immunodeficiency Virus Type 1

Christos J. Petropoulos, Neil Parkin, Kay Limoli et al. · Antimicrobial Agents and Chemotherapy · 2000 · 653 citations

Life Sciences, Molecular Biology, Pharmacology +17

A Mechanism of AZT Resistance

Peter R. Meyer, S. Matsuura, A. Mohsin Mian et al. · Molecular Cell · 1999 · 343 citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids

Stefan G. Sarafianos, Kalyan Das, Arthur D. Clark et al. · Proceedings of the National Academy of Sciences · 1999 · 306 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17