A Mechanism of AZT Resistance

Peter R. Meyer, S. Matsuura, A. Mohsin Mian, +2

Molecular Cell

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

Peter R. Meyer, S. Matsuura, Antero G. So, +1

Proceedings of the National Academy of Sciences

Differential Removal of Thymidine Nucleotide Analogues from Blocked DNA Chains by Human Immunodeficiency Virus Reverse Transcriptase in the Presence of Physiological Concentrations of 2′-Deoxynucleoside Triphosphates

Peter R. Meyer, S. Matsuura, Raymond F. Schinazi, +2

Antimicrobial Agents and Chemotherapy

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Peter R. Meyer, S. Matsuura, Dianna L. Zonarich, +5

Journal of Virology

Foscarnet-resistant MutantsViral ReplicationMolecular BiologyAntiviral DrugDrug Resistance +17

Effects of Specific Zidovudine Resistance Mutations and Substrate Structure on Nucleotide-Dependent Primer Unblocking by Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Peter R. Meyer, S. Matsuura, Adviye Ayper Tolun, +4

Antimicrobial Agents and Chemotherapy

Effects of Dipeptide Insertions between Codons 69 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Primer Unblocking, Deoxynucleoside Triphosphate Inhibition, and DNA Chain Elongation

Peter R. Meyer, Johan Lennerstrand, S. Matsuura, +2

Journal of Virology

Viral ReplicationUnblocking ActivityGeneticsImmunologyMolecular Biology +14

Effects of Primer-Template Sequence on ATP-dependent Removal of Chain-terminating Nucleotide Analogues by HIV-1 Reverse Transcriptase

Peter R. Meyer, Anthony J. Smith, S. Matsuura, +1

Journal of Biological Chemistry

Viral ReplicationNucleic Acid ChemistryBiochemistryNatural SciencesHuman Retrovirus +13

Intracellular Substrates for the Primer-Unblocking Reaction by Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Detection and Quantitation in Extracts from Quiescent- and Activated-Lymphocyte Subpopulations

Anthony J. Smith, Peter R. Meyer, Deshratn Asthana, +2

Antimicrobial Agents and Chemotherapy

Viral ReplicationPrimer-unblocking ReactionImmunologyMolecular BiologyAntiviral Drug +19

Stable Complexes Formed by HIV-1 Reverse Transcriptase at Distinct Positions on the Primer-template Controlled by Binding Deoxynucleoside Triphosphates or Foscarnet

Peter R. Meyer, Wiriya Rutvisuttinunt, S. Matsuura, +2

Journal of Molecular Biology

Stable Complexes FormedViral ReplicationProtein FoldingMedicineNatural Sciences +9

Chain-Terminating Dinucleoside Tetraphosphates Are Substrates for DNA Polymerization by Human Immunodeficiency Virus Type 1 Reverse Transcriptase with Increased Activity against Thymidine Analogue-Resistant Mutants

Peter R. Meyer, Anthony J. Smith, S. Matsuura, +1

Antimicrobial Agents and Chemotherapy

Viral ReplicationMolecular BiologyChemical BiologyMedicinal ChemistryMutant Hiv-1 +16