HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

B. A. Larder, G. Darby, Douglas D. Richman

Science

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

Huifang Huang, Rajiv Chopra, Gregory L. Verdine, +1

Science

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair, +7

Proceedings of the National Academy of Sciences

Viral ReplicationThymidine AnalogImmunologyMolecular BiologyAntiviral Drug +16

The "megaprimer" method of site-directed mutagenesis.

Gobinda Sarkar, S S Sommer

PubMed

EngineeringGeneticsOligonucleotide PrimersMolecular BiologyMolecular Genetics +16

The Accuracy of Reverse Transcriptase from HIV-1

John D. Roberts, Katarzyna Bębenek, Thomas A. Kunkel

Science

Viral ReplicationReverse GeneticsImmunologyMolecular BiologyHuman Retrovirus +14

Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography.

Barry R. Bochner, B N Ames

Journal of Biological Chemistry

Phenotypic Mechanism of HIV-1 Resistance to 3‘-Azido-3‘-deoxythymidine (AZT):  Increased Polymerization Processivity and Enhanced Sensitivity to Pyrophosphate of the Mutant Viral Reverse Transcriptase

Dominique Arion, Neerja Kaushik, Suzanne McCormick, +2

Biochemistry

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

Peter R. Meyer, S. Matsuura, Antero G. So, +1

Proceedings of the National Academy of Sciences

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

M H St Clair, C A Richards, T Spector, +4

Antimicrobial Agents and Chemotherapy

ImmunologyMolecular BiologyAntiviral DrugChemical BiologyMedicinal Chemistry +14

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

Ying‐Chih Cheng, Ginger E. Dutschman, Kenneth F. Bastow, +1

Journal of Biological Chemistry