A Mechanism of AZT Resistance

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

B. A. Larder, G. Darby, Douglas D. Richman · Science · 1989 · 1.6K citations

Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

Huifang Huang, Rajiv Chopra, Gregory L. Verdine et al. · Science · 1998 · 1.4K citations

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair et al. · Proceedings of the National Academy of Sciences · 1986 · 1.3K citations · Full text

Viral Replication, Thymidine Analog, Immunology +18

The "megaprimer" method of site-directed mutagenesis.

Gobinda Sarkar, S S Sommer · PubMed · 1990 · 1.2K citations

Engineering, Genetics, Oligonucleotide Primers +18

The Accuracy of Reverse Transcriptase from HIV-1

John D. Roberts, Katarzyna Bębenek, Thomas A. Kunkel · Science · 1988 · 979 citations

Viral Replication, Reverse Genetics, Immunology +16