James A. Fyfe

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

Gertrude B. Elion, Phillip A. Furman, James A. Fyfe et al. · Proceedings of the National Academy of Sciences · 1977 · 1.6K citations · Full text

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair et al. · Proceedings of the National Academy of Sciences · 1986 · 1.3K citations · Full text

Viral Replication, Thymidine Analog, Immunology +18

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

James A. Fyfe, Paul M. Keller, P A Furman et al. · Journal of Biological Chemistry · 1978 · 561 citations · Full text

Medicine, Herpes Simplex Virus, Antiviral Drug Development +8

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity.

Paula Sherman, James A. Fyfe · Proceedings of the National Academy of Sciences · 1990 · 330 citations · Full text

Viral Replication, Molecular Biology, Reaction Selectivity +17

Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

P A Furman, M H St Clair, James A. Fyfe et al. · Journal of Virology · 1979 · 327 citations · Full text

Viral Replication, Molecular Virology, Biochemistry +8