Synthesis of 2,3-diaryl-1,3-thiazolidine-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 1.9K citations · Full text

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

Ravi G. Kurumbail, Anna M. Stevens, James K. Gierse et al. · Nature · 1996 · 1.9K citations

Inflammation, Medicinal Chemistry, Anti-inflammatory +10

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Wei Xie, Jeffrey G. Chipman, Donald Robertson et al. · Proceedings of the National Academy of Sciences · 1991 · 1.7K citations · Full text

Src-transformed Cells, Mrna Splicing, Rna Splicing +23

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

Jianmin Fu, Jaime L. Masferrer, Karen Seibert et al. · Journal of Biological Chemistry · 1990 · 941 citations · Full text

Lipid Peroxidation, Immunology, Thromboxane A2 +22

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

Toshihiko Kawamori, Chinthalapally V. Rao, Karen Seibert et al. · PubMed · 1998 · 924 citations

Anti-inflammatory, Oncology, Colon Carcinogenesis +13