Concepedia

ALTERED AZT (3′-AZIDO-3′-DEOXYTHYMIDINE) GLUCURONIDATION KINETICS IN LIVER MICROSOMES AS AN EXPLANATION FOR UNDERPREDICTION OF IN VIVO CLEARANCE: COMPARISON TO HEPATOCYTES AND EFFECT OF INCUBATION ENVIRONMENT

Juntyma J. Engtrakul, R. Foti, Timothy J. Strelevitz, Michael B. Fisher

Drug Metabolism and Disposition · 2005 · 68 citations · 43 references

DOI

Concepts

References

43

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Kaoxiang Sun · Chinese New Drugs Journal · 2005 · 764 citations

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The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data

R. Scott Obach, James G. Baxter, Theodore E. Liston et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 591 citations

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The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

Rupert P. Austin, Patrick Barton, Scott L. Cockroft et al. · Drug Metabolism and Disposition · 2002 · 407 citations

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In Vitro Glucuronidation Using Human Liver Microsomes and The Pore-Forming Peptide Alamethicin

Michael B. Fisher, Kristina Campanale, Bradley L. Ackermann et al. · Drug Metabolism and Disposition · 2000 · 342 citations

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