Concepedia

Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells

F. E. Bertrand, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, J G Shelton, Edmond R. White, Dale L. Ludwig, James A. McCubrey

Leukemia · 2006 · 77 citations · 15 references

DOI

Concepts

References

15

Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry

Ki Y. Chung, Jinru Shia, Nancy E. Kemeny et al. · Journal of Clinical Oncology · 2005 · 1.1K citations · Full text

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Insulin-like Growth Factor-I Receptor/Human Epidermal Growth Factor Receptor 2 Heterodimerization Contributes to Trastuzumab Resistance of Breast Cancer Cells

Rita Nahta, Linda X.H. Yuan, Bing Zhang et al. · Cancer Research · 2005 · 801 citations

, , +17

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

Constantine S. Mitsiades, Nicholas Mitsiades, Ciaran J. McMullan et al. · Cancer Cell · 2004 · 611 citations

, , +17

Combination Therapy Enhances the Inhibition of Tumor Growth with the Fully Human Anti–Type 1 Insulin-Like Growth Factor Receptor Monoclonal Antibody CP-751,871

Bruce D. Cohen, Deborah A. Baker, Catherine Soderstrom et al. · Clinical Cancer Research · 2005 · 362 citations · Full text

, , +17

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Douglas Burtrum, Zhenping Zhu, Dan Lu et al. · PubMed · 2003 · 349 citations

, , +15