William H. Chappell

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors

Linda S. Steelman, Patrick M. Navolanic, Melissa L. Sokolosky et al. · Oncogene · 2008 · 171 citations · Full text

Breast Oncology, Pten Function Increases, Medicine +7

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

Stephen L. Abrams, Linda S. Steelman, John G. Shelton et al. · Cell Cycle · 2010 · 136 citations · Full text

Drug Resistant Cells, Chemoprevention Strategy, Apoptosis +16

p53 expression controls prostate cancer sensitivity to chemotherapy and the MDM2 inhibitor Nutlin-3

William H. Chappell, Brian D. Lehmann, David M. Terrian et al. · Cell Cycle · 2012 · 110 citations · Full text

P53 Transcription Factor, P53 Expression Controls, Urology +12

Productive Replication of Human Papillomavirus 31 Requires DNA Repair Factor Nbs1

Daniel C. Anacker, Dipendra Gautam, Kenric A. Gillespie et al. · Journal of Virology · 2014 · 110 citations · Full text

A Dominant Role for p53-Dependent Cellular Senescence in Radiosensitization of Human Prostate Cancer Cells

Brian D. Lehmann, James A. McCubrey, Holly Jefferson et al. · Cell Cycle · 2007 · 101 citations · Full text