Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

Fumin Chang, Linda S. Steelman, John G. Shelton, +5

PubMed

ApoptosisCell DeathCell CycleCancer BiologyCell Death Mechanisms +17

The Raf/MEK/ERK pathway can govern drug resistance, apoptosis and sensitivity to targeted therapy

Stephen L. Abrams, Linda S. Steelman, John G. Shelton, +9

Cell Cycle

Drug Resistant CellsChemoprevention StrategyApoptosisCell DeathRaf/mek/erk Pathway +14

Synergy between PI3K/Akt and Raf/MEK/ERK Pathways in IGF-1R Mediated Cell Cycle Progression and Prevention of Apoptosis in Hematopoietic Cells

John G. Shelton, Linda S. Steelman, Edmond R. White, +1

Cell Cycle

ApoptosisImmunologyCell DeathIgf-1r-mediated Signal TransductionCell Cycle +16

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells

John G. Shelton, Linda S. Steelman, John Tayu Lee, +8

Oncogene

CytokineSignal TransductionSignaling PathwayCell RegulationHematopoietic Cells +8

Solubility and Bioactivity of the <i>Pseudomonas</i> Quinolone Signal Are Increased by a <i>Pseudomonas aeruginosa</i> -Produced Surfactant

M. Worth Calfee, John G. Shelton, James A. McCubrey, +1

Infection and Immunity

Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs

Linda S. Steelman, Stephen L. Abrams, John G. Shelton, +8

Cell Cycle

Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection

Shaw M. Akula, Patrick W. Ford, Audy G. Whitman, +3

Oncogene

MedicineViral PathogenesisVirologyHerpesviruses

Ability of the Activated PI3K/Akt Oncoproteins to Synergize with MEK1 and Induce Cell Cycle Progression and Abrogate the Cytokine-Dependence of Hematopoietic Cells

John G. Shelton, William L. Blalock, Edmond R. White, +2

Cell Cycle

ImmunologyImmunologic MechanismCell CycleImmunotherapyActivated Pi3k/akt Oncoproteins +17

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy

Stephen L. Abrams, Linda S. Steelman, John G. Shelton, +8

Cell Cycle

ApoptosisImmunologyCell DeathPharmacotherapySignal Transduction Inhibitors +16

Conditional EGFR Promotes Cell Cycle Progression and Prevention of Apoptosis in the Absence of Autocrine Cytokines

John G. Shelton, Linda S. Steelman, Steven L. Abrams, +6

Cell Cycle