J G Shelton

Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells

F. E. Bertrand, Linda S. Steelman, William H. Chappell et al. · Leukemia · 2006 · 77 citations

Medicine, Hematology, Oncology +15

Interactions between the PI3K and Raf signaling pathways can result in the transformation of hematopoietic cells.

James A. McCubrey, J. T. Lee, Linda S. Steelman et al. · PubMed · 2001 · 62 citations

Life Sciences, Cell Biology, Molecular Biology +10

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia

William L. Blalock, Patrick M. Navolanic, Linda S. Steelman et al. · Leukemia · 2003 · 55 citations

Life Sciences, Cancer Biology, Cell Biology +16

Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

J G Shelton, P W Moye, Linda S. Steelman et al. · Leukemia · 2003 · 49 citations

Life Sciences, Cell Biology, Oncology +16

Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support

F. E. Bertrand, J D Spengemen, J G Shelton et al. · Leukemia · 2004 · 39 citations

Life Sciences, Cell Biology, Molecular Biology +16