Concepedia

Inhibition of PI3K, mTOR and MEK signaling pathways promotes rapid apoptosis in B-lineage ALL in the presence of stromal cell support

F. E. Bertrand, J D Spengemen, J G Shelton, James A. McCubrey

Leukemia · 2004 · 39 citations · 19 references

DOI

Concepts

References

19

Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell–derived factor-1

Jan A. Burger, Nobuhiro Tsukada, Meike Burger et al. · Blood · 2000 · 734 citations · Full text

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Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

Marina Konopleva, Sergej Konoplev, Wei Hu et al. · Leukemia · 2002 · 386 citations

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Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms

Yulia Nefedova, T H Landowski, William S. Dalton · Leukemia · 2003 · 246 citations

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Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy

Ryan E. Mudry, James Fortney, Teresa York et al. · Blood · 2000 · 216 citations

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Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

Atsushi Manabe, KG Murti, Elaine Coustan‐Smith et al. · Blood · 1994 · 159 citations · Full text

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