Douglas Burtrum

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Douglas Burtrum, Zhenping Zhu, Dan Lu et al. · PubMed · 2003 · 349 citations

Medicine, Oncology, Pharmacology +15

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

Jerzy P. Szaflarski, Douglas Burtrum, Faye S. Silverstein · Stroke · 1995 · 281 citations

Life Sciences, Neurobiology, Neuroscience +17

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

Svetlana M. Mazel, Douglas Burtrum, Howard T. Petrie · The Journal of Experimental Medicine · 1996 · 276 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

Howard T. Petrie, Ferenc Livák, Douglas Burtrum et al. · The Journal of Experimental Medicine · 1995 · 175 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Simultaneous Blockade of Both the Epidermal Growth Factor Receptor and the Insulin-like Growth Factor Receptor Signaling Pathways in Cancer Cells with a Fully Human Recombinant Bispecific Antibody

Dan Lu, Haifan Zhang, Dale L. Ludwig et al. · Journal of Biological Chemistry · 2004 · 125 citations · Full text

Pharmacy, Oncology, Pharmacology +17