Degradation of CFTR by the ubiquitin-proteasome pathway

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

John R. Riordan, Johanna M. Rommens, Bat-Sheva Kerem et al. · Science · 1989 · 7.4K citations

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis

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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Gabriel Fenteany, Robert F. Standaert, William S. Lane et al. · Science · 1995 · 1.6K citations

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Crystal Structure of the 20 <i>S</i> Proteasome from the Archaeon <i>T. acidophilum</i> at 3.4 Å Resolution

Jan Löwe, Daniela Stock, Bing K. Jap et al. · Science · 1995 · 1.5K citations

Humanities, Anthropology, Archaeology +17