Restoration of Growth Arrest by p16INK4, p21WAF1, pRB, and p53 Is Dependent on the Integrity of the Endogenous Cell-Cycle Control Pathways in Human Glioblastoma Cell Lines

WAF1, a potential mediator of p53 tumor suppression

Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations

Life Sciences, Genetics, Molecular Biology +13

p21 is a universal inhibitor of cyclin kinases

Yue Xiong, Gregory J. Hannon, Hui Zhang et al. · Nature · 1993 · 3.4K citations

Life Sciences, Cell Biology, Molecular Biology +14

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Adrian Merlo, James G. Herman, Li Mao et al. · Nature Medicine · 1995 · 2K citations

Medicine, Genetics, Molecular Biology +17

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

Vjekoslav Dulić, William K. Kaufmann, S J Wilson et al. · Cell · 1994 · 1.5K citations

Medicine, Cell Biology, Oncology +17

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

Xavier Graña, E. Premkumar Reddy · PubMed · 1995 · 1.1K citations

Life Sciences, Cell Biology, Molecular Biology +17